Structured Illumination Microscopy (SIM)

Vala’s Structured Illumination Microscopy (SIM™) matches the resolution of best-in-class confocal microscopes at the fast speed of lower-resolution drug screening tools.  SIM offers the smallest footprint, with the best ease-of-use, and at half the price of competing tools.

SIM combines the greatest resolution and speed (whereas all competitors sacrifice one for the other)  –  for even more disease-sensitive details – in a compact, easy-to-use and value-priced tool that virtually all scientists crave, and can now afford.


Combining KIC & SIM

Adding SIM to KIC creates 3D imaging with resolution equal to that of single-spot laser-scanning confocal microscopy (sLSCM) at the lowest possible phototoxicity (wide field excitation) with plate scanning speeds comparable to spinning disk systems, which exhibit resolution only about ½-way between sLCSM and wide field instruments. SIM thus combines the greatest resolution and speed (whereas all competitors sacrifice one for the other)  –  for even more disease-sensitive details – at the lowest possible phototoxicity for drug discovery and mechanistic biological assays in high throughput screens via fast kinetics of temperamental cell models such as iPSC-cardiomyocytes and –neurons.