High Content Screening Services

High Content Screening Services

  • As an EPA-certified subcontractor and assay provider for the ToxCAST screening program, we were recently awarded an “Exceptional” rating for services provided.
  • Collaborative approach to assay development and data analysis
  • Specialize in custom assays using advanced models including iPS-derived cells
  • Focus on high quality data and biological relevance

Please contact us for your free assay development consultation.

 

Cardiotoxicity Screening

Calcium is central to the contractile performance of cardiomyocytes where it serves as the final integrator of the electrical signals generated by the myriad of ion channels that produce the cardiac action potential. Changes to the cardiac action potential due to perturbations in the function of any of these ion channels will lead to the alteration of Ca2+ transient dynamics.

Vala Sciences Kinetic Image Cytometer (KIC) allows for cell by cell analysis of calcium transient dynamics on hundreds of cells per well in an automated high throughput manner facilitating the rapid screening of thousands of compounds for cardiac arrythmogenic liabilities. Furthermore, KIC enables recording of transients from spontaneously beating cells or electrically paced cells via an integrated cell stimulator.

Custom HCS Assays

With a portfolio of over 100 HCS assays to choose from, we are able to tailor any assay to meet the exacting needs of our clients.

  • Apoptosis
  • Angiogenesis
  • Adipogenesis
  • Cell-cell junctions and cadheriins
  • Cell migration
  • Lipolysis
  • MAP kinase pathways
  • Mitochondrial Health
  • Neural Crest Differentiation
  • Neural Crest Migration
  • Neuronal Differentiation
  • Neuronal Function
  • Steatosis
  • Wound healing
  • Wnt signaling

Our team of industry-experienced, PhD-level scientists work collaboratively with you, further developing each assay to have the right biological focus and give you the most pertinent data in the most convenient format possible.

Please contact us for your free assay development consultation.